 John GoodmanThe Dean (segment "Happy Birthday") | The Dean (segment "Happy Birthday") |
 Sydney Tamiia PoitierHannah (segment "Happy Birthday") | Hannah (segment "Happy Birthday") |
 Beverly D'AngeloBag Lady (segment "Happy Birthday") | Bag Lady (segment "Happy Birthday") |
 Christopher LloydAttorney Bum (segment "Happy Birthday") | Attorney Bum (segment "Happy Birthday") |
 David Hyde PierceBarney (segment "Happy Birthday") | Barney (segment "Happy Birthday") |
 Caroline RheaMonica (segment "Happy Birthday") | Monica (segment "Happy Birthday") |
 Jenica BergereSally (segment "Happy Birthday") | Sally (segment "Happy Birthday") |
 Ken Hudson CampbellSecurity Guard (segment "Happy Birthday") | Security Guard (segment "Happy Birthday") |
| RRoman DanyloDonald (segment "Happy Birthday") | Donald (segment "Happy Birthday") |
 Kimiko GelmanMay Lee Ha (segment "Happy Birthday") | May Lee Ha (segment "Happy Birthday") |
 Jean KasemNurse (segment "Happy Birthday") | Nurse (segment "Happy Birthday") |
 Taylor NegronPoliceman (segment "Happy Birthday") | Policeman (segment "Happy Birthday") |
 Travis WesterChute Boy (segment "Happy Birthday") | Chute Boy (segment "Happy Birthday") |
 Dondré WhitfieldMan in Elevator (segment "Happy Birthday") | Man in Elevator (segment "Happy Birthday") |
 Marissa Jaret WinokurDean's Secretary (segment "Happy Birthday") | Dean's Secretary (segment "Happy Birthday") |
 Bruce Davison(segment "The Other Side") | (segment "The Other Side") |
 Anthony LaPagliaDr. Maas (segment "The Other Side") | Dr. Maas (segment "The Other Side") |
 Karen SillasAnna (segment "The Other Side") | Anna (segment "The Other Side") |
 Andie MacDowellLisa (segment "Reaching Normal") | Lisa (segment "Reaching Normal") |
 Paul RuddKenneth (segment "Reaching Normal") | Kenneth (segment "Reaching Normal") |
 Joey Lauren AdamsSarah (segment "Reaching Normal") | Sarah (segment "Reaching Normal") |
 Alan RosenbergFrank (segment "Reaching Normal") | Frank (segment "Reaching Normal") |
 Joel GreyDr. Mensley (segment "Reaching Normal") | Dr. Mensley (segment "Reaching Normal") |
 Jolene BlalockCharlie's Wife (wraparound segments) | Charlie's Wife (wraparound segments) |
 Scott LowellCharlie (wraparound segments) | Charlie (wraparound segments) |
 Stephen TobolowskyTom (wraparound segments) | Tom (wraparound segments) |
 Kathleen WilhoiteLucy (wraparound segments) | Lucy (wraparound segments) |
 Ellen DeGeneresOperator (segment "Reaching Normal") (uncredited) | Operator (segment "Reaching Normal") (uncredited) |
 Helen MirrenDistinguished Woman (segment "Happy Birthday") (uncredited) | Distinguished Woman (segment "Happy Birthday") (uncredited) |
