Two ranch workers, one of them simple-minded, look for work and happiness during the Great Depression, but luck is not in their cards.
| Actor | Role |
|---|---|
 George SegalGeorge | George |
 Nicol WilliamsonLennie | Lennie |
 Dana ElcarNot listed | Not listed |
 Will GeerCandy | Candy |
 Don GordonCurly | Curly |
 Moses GunnCrooks | Crooks |
| JJames HallNot listed | Not listed |
| JJoey HeathertonCurly's Wife | Curly's Wife |
 Donald MoffatSlim | Slim |
 John RandolphNot listed | Not listed |