After a family visit, stressed businesswoman Senga Wilson is driving with her rebellious daughter, Nat, down an ominous highway in the middle of the night. After they pick up a weird teenage hitchhiker, their journey goes awry. Nat decides to give her mom the slip and runs off with the hitchhiker at a rest stop. In a desperate search to find her daughter, Senga learns that Nat has been drawn into an evil cult.
| Actor | Role |
|---|---|
 Madeleine StoweSenga Wilson | Senga Wilson |
 Norman ReedusRecovery Man | Recovery Man |
 Bijou PhillipsBackpacker | Backpacker |
 Mischa BartonNatasha 'Nat' Wilson | Natasha 'Nat' Wilson |
 Jonathan Rhys MeyersThe Father | The Father |
 Leo GregoryJoyrider | Joyrider |
 Martin McDougallMotivational Speaker | Motivational Speaker |
| GGary ParkerVacation Man | Vacation Man |
| AAmber BattyVacation Woman | Vacation Woman |
 Jenny JulesHighway Patrol Sergeant | Highway Patrol Sergeant |
 Patrick O'KaneTrucker | Trucker |
 Samuel FrölerMarek Wilson | Marek Wilson |
| EEmma DrewsTeenage Girl in Video | Teenage Girl in Video |
| VVéronique KochCashier #1 (as Veronique Koch) | Cashier #1 (as Veronique Koch) |
 Sam DouglasCrash Site Detective | Crash Site Detective |
| TTom HunsingerCSI Man | CSI Man |
 Glenn WrageHighway Patrol Cop #2 | Highway Patrol Cop #2 |
 Raffaello DegruttolaHighway Patrol Cop #1 | Highway Patrol Cop #1 |
 Nigel WhitmeyDetective Ned Stephens | Detective Ned Stephens |
 David MenkinParamedic #2 | Paramedic #2 |
 Shauna ShimParamedic #1 | Paramedic #1 |