A mixture of rapture and disenchantment, O HOLY GHOST follows the inner experiences of two believers at opposite ends of the spiritual spectrum.
| Actor | Role |
|---|---|
 Fehinti BalogunEmmanuel | Emmanuel |
 Ben WhishawCharmaine | Charmaine |
 Kelly CampbellDebbie | Debbie |
 Anna SavvaZealous Member | Zealous Member |
 Emma D'ArcyStephanie | Stephanie |
 Marlene MadengeHoly Ghost Zone Member | Holy Ghost Zone Member |
 Sadao UedaHoly Ghost Zone Member | Holy Ghost Zone Member |
 Takako AkashiPrayer Warrior | Prayer Warrior |
| MMary BennHoly Ghost Zone Member | Holy Ghost Zone Member |
| CChristopher LoganPrayer Warrior | Prayer Warrior |
| CClaudia CapperHoly Ghost Zone Member | Holy Ghost Zone Member |
| SScott WarkHoly Ghost Zone Member | Holy Ghost Zone Member |
| ZZubin KangaHoly Ghost Zone Member | Holy Ghost Zone Member |
| GGemma JohnsonDespondent Member | Despondent Member |
| DDavid RawlinsPrayer Warrior | Prayer Warrior |