Story of the personal lives and careers of three female doctors, from different backgrounds and walks of life, who work at a San Francisco county hospital.
| Actor | Role |
|---|---|
 Gail O'GradyDr. Page Taylor | Dr. Page Taylor |
 Brooke ShieldsDr. Beth Taft | Dr. Beth Taft |
 Vanessa WilliamsDr. Kathy 'Kat' Hunter | Dr. Kathy 'Kat' Hunter |
 Gregory HarrisonDr. Benjamin 'Ben' Wallace | Dr. Benjamin 'Ben' Wallace |
 Stephen CaffreyJason Curtis | Jason Curtis |
 Chris NothDr. Ken Mallory | Dr. Ken Mallory |
 T.J. LowtherAaron Lomax | Aaron Lomax |
 Gerald McRaneyDr. Lawrence Barker | Dr. Lawrence Barker |
 Leo GeterDr. Ben Mills | Dr. Ben Mills |