Captives of the very relationships that define and sustain them, nine women resiliently meet the travails and disappointments of life.
| Actor | Role |
|---|---|
 Kathy BakerCamille | Camille |
 Amy BrennemanLorna | Lorna |
 Elpidia CarrilloSandra | Sandra |
 Glenn CloseMaggie | Maggie |
 Stephen DillaneMartin | Martin |
 Dakota FanningMaria | Maria |
 William FichtnerAndrew | Andrew |
 LisaGay HamiltonHolly | Holly |
 Holly HunterSonia | Sonia |
 Jason IsaacsDamien | Damien |
 Joe MantegnaRichard | Richard |
 Ian McShaneLarry | Larry |
 Molly ParkerLisa | Lisa |
 Mary Kay PlaceDr. Alma Wyatt | Dr. Alma Wyatt |
 Sydney Tamiia PoitierVanessa | Vanessa |
 Aidan QuinnHenry | Henry |
 Miguel SandovalDeputy Sheriff Ron | Deputy Sheriff Ron |
 Amanda SeyfriedSamantha | Samantha |
 Sissy SpacekRuth | Ruth |
 Robin WrightDiana | Diana |
 K CallanMarisa | Marisa |
 Lawrence PressmanRoman | Roman |
| AAomawa BakerFemale Guard | Female Guard |
| MMary Pat DowhyNicole | Nicole |
 Andy UmbergerSecond Male Guard | Second Male Guard |
 Chelsea RendonSandra's Daughter | Sandra's Daughter |
 Daniel Edward MoraReceptionist | Receptionist |
 Pat MusickMourner / Night Manager | Mourner / Night Manager |
 Rebecca TilneyRebecca | Rebecca |
 Andrew BorbaPaul | Paul |