 John BarrymoreRiviere | Riviere |
 Helen HayesMadame Fabian | Madame Fabian |
 Clark GableJules | Jules |
 Lionel BarrymoreRobineau | Robineau |
 Robert MontgomeryAuguste Pellerin | Auguste Pellerin |
 Myrna LoyWife of Brazilian Pilot | Wife of Brazilian Pilot |
 William GarganBrazilian Pilot | Brazilian Pilot |
 C. Henry GordonDaudet | Daudet |
 Leslie FentonJules' Radio Operator / Co-Pilot | Jules' Radio Operator / Co-Pilot |
 Harry BeresfordPierre Roblet | Pierre Roblet |
 Frank ConroyRadio Operator | Radio Operator |
 Dorothy BurgessPellerin's Girlfriend | Pellerin's Girlfriend |
 Irving PichelDr. Decosta | Dr. Decosta |
 Helen Jerome EddyWorried Mother | Worried Mother |
 Buster PhelpsSick Child | Sick Child |
 Ralf HaroldePilot | Pilot |
 Marcia RalstonNightclub Vamp | Nightclub Vamp |
 Maurice BlackNightclub Manager (uncredited) | Nightclub Manager (uncredited) |
 Ed BradyRadio Operator on Telephone (uncredited) | Radio Operator on Telephone (uncredited) |
 Sidney D'AlbrookAirport Office Employee (uncredited) | Airport Office Employee (uncredited) |
 Claire Du BreySantiago Nurse (uncredited) | Santiago Nurse (uncredited) |
| SSherry HallAirport Office Employee (uncredited) | Airport Office Employee (uncredited) |
 Otto HoffmanAirport Office Clerk (uncredited) | Airport Office Clerk (uncredited) |
 George IrvingSantiago Doctor (uncredited) | Santiago Doctor (uncredited) |
 Wallace MacDonaldMechanic (uncredited) | Mechanic (uncredited) |
 Michael MarkAirport Office Employee (uncredited) | Airport Office Employee (uncredited) |
 Francis McDonaldRadioman (uncredited) | Radioman (uncredited) |
 Louis NatheauxRadioman (uncredited) | Radioman (uncredited) |
 Inez PalangeSimone's Maid (uncredited) | Simone's Maid (uncredited) |
 Edward Peil Sr.Airport Office Employee (uncredited) | Airport Office Employee (uncredited) |
