Nene Raju Nene Mantri is the story of Radha Jogendra and the love of his life, Radha. His whole world revolves around her and he can go to any lengths to make her happy. But what happens when such profound love takes the shape of cavernous ambition?
| Actor | Role |
|---|---|
 Rana DaggubatiJogendra | Jogendra |
 Kajal AggarwalRadha Jogendra | Radha Jogendra |
 Catherine TresaDevika Rani | Devika Rani |
 NavdeepShiva | Shiva |
 Ashutosh RanaSubbarayudu | Subbarayudu |
| RRavi JoshiTirupathi | Tirupathi |
 Jayaprakash Reddythe jailor | the jailor |
 Posani Krishna MuraliMuniappa | Muniappa |
 Pradeep Ram Singh RawatSarpanch | Sarpanch |
 Tanikella BharaniChief Minister | Chief Minister |
 Shivaji RajaRadha's Father | Radha's Father |
 AjayCI/SP | CI/SP |
 Raghu KarumanchiChandramouli | Chandramouli |
 Prabhas SreenuSubbarayudu's PA | Subbarayudu's PA |
 Bitthiri SatthiNews Reporter | News Reporter |
 Satya PrakashMLA Choudappa | MLA Choudappa |
 Bindu ChandramouliSarpanch's Wife | Sarpanch's Wife |
 Venkateswara Rao ParuchuriJail Lawyer | Jail Lawyer |
 Naveen NeniRavi | Ravi |
 Priyanka NalkariSushmitha | Sushmitha |
 AnnapoornaNot listed | Not listed |