 Helen HayesLucille Jefferson | Lucille Jefferson |
 Van HeflinStedman | Stedman |
 Dean JaggerDan Jefferson | Dan Jefferson |
 Robert WalkerJohn Jefferson | John Jefferson |
 Minor WatsonDr. Carver | Dr. Carver |
 Frank McHughFather O'Dowd | Father O'Dowd |
 Richard JaeckelChuck Jefferson | Chuck Jefferson |
 James YoungBen Jefferson | Ben Jefferson |
| JJimmie DundeeTaxi Driver (uncredited) | Taxi Driver (uncredited) |
 Douglas EvansGovernment Employee (uncredited) | Government Employee (uncredited) |
 Nancy HaleNurse (uncredited) | Nurse (uncredited) |
| SSam HarrisProfessor at Graduation Ceremony (uncredited) | Professor at Graduation Ceremony (uncredited) |
 Todd KarnsBedford (uncredited) | Bedford (uncredited) |
 Leo McCareyJohn Jefferson (voice) (uncredited) | John Jefferson (voice) (uncredited) |
 Lee MillerPoliceman at Shooting Scene (uncredited) | Policeman at Shooting Scene (uncredited) |
 David NewellFBI Agent (uncredited) | FBI Agent (uncredited) |
| VVera StokesSecretary (uncredited) | Secretary (uncredited) |
| FFred SweeneyCleaner (uncredited) | Cleaner (uncredited) |
| MMargaret WellsNurse (uncredited) | Nurse (uncredited) |
