My Sassy Husband follows Yoyo Ma and Thirteen Cheung’s union 10 years later to present day where they are experiencing marital problems. After they realize that their wedding ceremony held in London is not considered official in Hong Kong, they decide to part ways in search of their real love. While Yoyo and Thirteen both start dating new prospects, will they end up back together?
| Actor | Role |
|---|---|
 Ekin Cheng Yee-KinThirteen | Thirteen |
 Charlene Choi Chuek-YinYoyo Ma | Yoyo Ma |
 Zhang XinyiTung Yi | Tung Yi |
 Xu ZhengxiFrancis Lin | Francis Lin |
 Joyce Cheng Yan-YiNana | Nana |
 Lo Hoi-PangUncle 6 | Uncle 6 |
 Susan Shaw Yam-YamAuntie 6 | Auntie 6 |
 Wong Cho-LamMr Lee | Mr Lee |
 JJ JiaMrs Lee | Mrs Lee |
 Sandy Lam San-SanSister | Sister |
 Kelvin KwanGas delivery man | Gas delivery man |
 Derek Tsang Kwok-CheungRobber | Robber |
 Louis CheungLouis, photographer | Louis, photographer |
| WWylie ChiuJosephine Wong, diving instructor | Josephine Wong, diving instructor |
| NNelson Cheung Hok-YunTung Yi's manager | Tung Yi's manager |
| CChu FunMrs Chow | Mrs Chow |
 Renee DaiMrs Tam | Mrs Tam |
 Jacqueline ChanYoung Yoyo | Young Yoyo |
 Leanne Foo Hiu-MeiPoolside party girl | Poolside party girl |
 Zaneta WongPoolside Party Girl | Poolside Party Girl |
 Jackie Xu Jia-QiFiancee Kitty | Fiancee Kitty |
 Elva Ni Chen-XiAnnie | Annie |
 Au Hin-WaiNot listed | Not listed |
 Ben Yuen Foo-WahNot listed | Not listed |