 Henry FondaWyatt Earp | Wyatt Earp |
 Linda DarnellChihuahua | Chihuahua |
 Victor MatureDr. John 'Doc' Holliday | Dr. John 'Doc' Holliday |
 Cathy DownsClementine Carter | Clementine Carter |
 Walter BrennanOld Man Clanton | Old Man Clanton |
 Tim HoltVirgil Earp | Virgil Earp |
 Ward BondMorgan Earp | Morgan Earp |
 Alan MowbrayGranville Thorndyke | Granville Thorndyke |
 John IrelandBilly Clanton | Billy Clanton |
 Roy RobertsMayor | Mayor |
 Jane DarwellKate Nelson | Kate Nelson |
 Grant WithersIke Clanton | Ike Clanton |
 J. Farrell MacDonaldMac the barman | Mac the barman |
 Russell SimpsonJohn Simpson | John Simpson |
 Robert AdlerStagecoach Driver (uncredited) | Stagecoach Driver (uncredited) |
 C.E. AndersonTownsman (uncredited) | Townsman (uncredited) |
 Don BarclayOpera House Owner (uncredited) | Opera House Owner (uncredited) |
 Hank BellOpera House Patron (uncredited) | Opera House Patron (uncredited) |
| DDanny BorzageAccordionist (uncredited) | Accordionist (uncredited) |
 Ruth CliffordOpera House Patron (uncredited) | Opera House Patron (uncredited) |
| FFrank ConlanPianist (uncredited) | Pianist (uncredited) |
| TTex CooperTownsman (uncredited) | Townsman (uncredited) |
| JJack CurtisBartender (uncredited) | Bartender (uncredited) |
 William B. DavidsonSaloon Owner (uncredited) | Saloon Owner (uncredited) |
 Jimmy DimeVaquero (uncredited) | Vaquero (uncredited) |
 Tex DriscollTownsman (uncredited) | Townsman (uncredited) |
 Frank EllisBarfly (uncredited) | Barfly (uncredited) |
 Francis FordDad - Old Soldier (uncredited) | Dad - Old Soldier (uncredited) |
 Earle FoxeGambler (uncredited) | Gambler (uncredited) |
| DDon GarnerJames Earp (uncredited) | James Earp (uncredited) |
