 Ty BurrellMr. Peabody (voice) | Mr. Peabody (voice) |
 Max CharlesSherman (voice) | Sherman (voice) |
 Ariel WinterPenny Peterson (voice) | Penny Peterson (voice) |
 Allison JanneyMs. Grunion (voice) | Ms. Grunion (voice) |
 Stephen ColbertPaul Peterson (voice) | Paul Peterson (voice) |
 Stephen TobolowskyPrincipal Purdy (voice) | Principal Purdy (voice) |
 Stanley TucciLeonardo da Vinci (voice) | Leonardo da Vinci (voice) |
 Karan BrarMason (voice) | Mason (voice) |
 Joshua RushCarl (voice) | Carl (voice) |
 Adam Alexi-MalleFrench Peasant (voice) | French Peasant (voice) |
 Lauri FraserMarie Antoinette / Egyptian Woman (voice) | Marie Antoinette / Egyptian Woman (voice) |
 Leslie MannPatty Peterson (voice) | Patty Peterson (voice) |
 Lake BellMona Lisa (voice) | Mona Lisa (voice) |
 Guillaume AretosRobespierre (voice) | Robespierre (voice) |
 Pat MusickTeacher (voice) | Teacher (voice) |
 Dennis HaysbertJudge (voice) | Judge (voice) |
 Zach CallisonKing Tut (voice) | King Tut (voice) |
 Steve ValentineAy (voice) | Ay (voice) |
 Leila BirchWABAC Machine (voice) | WABAC Machine (voice) |
 Patrick WarburtonAgamemnon (voice) | Agamemnon (voice) |
 Tom McGrathOdysseus (voice) | Odysseus (voice) |
 Mel BrooksAlbert Einstein (voice) | Albert Einstein (voice) |
 Cullen McCarthyKid (voice) | Kid (voice) |
| JJasper Johannes AndrewsBaby Sherman (voice) | Baby Sherman (voice) |
 Walt DohrnFrench Peasant / Taxi Driver / Spartacus (voice) | French Peasant / Taxi Driver / Spartacus (voice) |
 Kim BubbsFrench Peasant (voice) | French Peasant (voice) |
 Nicholas GuestFrench Peasant (voice) | French Peasant (voice) |
 Thomas LennonItalian Peasant #2 (voice) | Italian Peasant #2 (voice) |
 Rob MinkoffCreepy Boy (voice) | Creepy Boy (voice) |
 Al RodrigoAjax (voice) | Ajax (voice) |
