Mr. Neighbors House 2 comically blurs the innocence of Mr. Rogers with the dark surrealism of David Lynch in a half hour, live action kids show that is too disturbing for kids. Mr. Neighbor (Brian Huskey) learns the importance of telling the truth. But only when he tells the whole truth can he open the Secret Door and save Neighborton! Join him as he faces his personal demons, struggles to keep a grip on reality and hopefully uncovers a hidden truth. You never know what you'll discover at Mr. Neighbor's House!
| Actor | Role |
|---|---|
 Brian HuskeyMr. Neighbor/Jim | Mr. Neighbor/Jim |
 Mary HollandMs. Lady/Nurse Mary/Patient 1 | Ms. Lady/Nurse Mary/Patient 1 |
 Marc Evan JacksonAubrey Duncan/Doctor/Patient 2 | Aubrey Duncan/Doctor/Patient 2 |
 David TheuneIce Cream Bruce/Patient 3 | Ice Cream Bruce/Patient 3 |
 Jerry MinorDetective | Detective |
 Seth MorrisFather | Father |
 Colleen SmithMother | Mother |
 Gil OzeriWolfe | Wolfe |
| MMeg DelancyScarlett | Scarlett |
 Jean VillepiqueCindy | Cindy |
 Victoria GraceCassidy | Cassidy |
 Joey McIntyreGame Show Host | Game Show Host |
 Amari O'NeilRicky | Ricky |
 Nathan ArenasEvan | Evan |
| JJenna DavisIngrid | Ingrid |
 Isabella DayFiona | Fiona |
 Jonathan KidderDuff and Daisy | Duff and Daisy |
 Michelle ZamoraCreeper | Creeper |
| AAdrian Rose LeonardBuddy | Buddy |