 Billy CrystalMike (voice) | Mike (voice) |
 John GoodmanSullivan (voice) | Sullivan (voice) |
 Steve BuscemiRandy (voice) | Randy (voice) |
 Helen MirrenDean Hardscrabble (voice) | Dean Hardscrabble (voice) |
 Peter SohnSquishy (voice) | Squishy (voice) |
 Joel MurrayDon (voice) | Don (voice) |
 Sean HayesTerri (voice) | Terri (voice) |
 Dave FoleyTerry (voice) | Terry (voice) |
 Charlie DayArt (voice) | Art (voice) |
 Alfred MolinaProfessor Knight (voice) | Professor Knight (voice) |
 Tyler LabineGreek Council VP (voice) | Greek Council VP (voice) |
 Nathan FillionJohnny (voice) | Johnny (voice) |
 Aubrey PlazaGreek Council President (voice) | Greek Council President (voice) |
 Bobby MoynihanChet (voice) | Chet (voice) |
 Noah JohnstonYoung Mike (voice) | Young Mike (voice) |
 Julia SweeneyMs. Squibbles (voice) | Ms. Squibbles (voice) |
 Bonnie HuntMrs. Graves (voice) | Mrs. Graves (voice) |
 John KrasinskiFrank McCay (voice) | Frank McCay (voice) |
 Bill HaderReferee / Slug (voice) | Referee / Slug (voice) |
 Beth BehrsPNK Carrie (voice) | PNK Carrie (voice) |
 Bob PetersonRoz (voice) | Roz (voice) |
 John RatzenbergerYeti (voice) | Yeti (voice) |
 Lori AlanAdditional Voices (voice) | Additional Voices (voice) |
 Carlos AlazraquiAdditional Voices (voice) | Additional Voices (voice) |
 Jack AngelAdditional Voices (voice) | Additional Voices (voice) |
 Bob BergenAdditional Voices (voice) | Additional Voices (voice) |
 Gregg BergerAdditional Voices (voice) | Additional Voices (voice) |
 Rodger BumpassAdditional Voices (voice) | Additional Voices (voice) |
 Neil CampbellAdditional Voices (voice) | Additional Voices (voice) |
 Patrick CarlyleAdditional Voices (voice) | Additional Voices (voice) |
