Father Kino, a 17th-century Jesuit missionary, dedicated his life to helping Native Americans in the Southwest by teaching them agricultural skills as well as building missions and spreading Christianity. An explorer, astronomer and map maker, Father Kino surmounted numerous challenges as he journeyed through California, Arizona and Mexico.
| Actor | Role |
|---|---|
 Richard EganEusibio Francisco Kino | Eusibio Francisco Kino |
 Ricardo MontalbanGeneral Lafuente | General Lafuente |
 John IrelandFather Mora | Father Mora |
 Joseph CampanellaFather at San Bruno Mission | Father at San Bruno Mission |
 Cesar RomeroJuan Atondo | Juan Atondo |
 Michael AnsaraChief Coxi | Chief Coxi |
 Keenan WynnFather at Trading Mission | Father at Trading Mission |
 John RussellSolis | Solis |
 Rory CalhounJuan Monje | Juan Monje |
 Anthony CarusoFather Rodriguez | Father Rodriguez |
 Aldo RayMine Boss | Mine Boss |
 Victor JoryFather Zaya | Father Zaya |
 William DozierFather Argula | Father Argula |
 Tristram CoffinFather Francesco Saeta | Father Francesco Saeta |
 Stephen McNallyJuan Salvatierra (uncredited) | Juan Salvatierra (uncredited) |