The friendship between two life-long girlfriends is put to the test when one starts a family and the other falls ill.
| Actor | Role |
|---|---|
 Drew BarrymoreJess | Jess |
 Toni ColletteMilly | Milly |
 Dominic CooperKit | Kit |
 Paddy ConsidineJago | Jago |
 Frances de la TourJill | Jill |
 Jacqueline BissetMiranda | Miranda |
 Tyson RitterAce | Ace |
 Kumud PantStaff at Charity Gala | Staff at Charity Gala |
 Noah HuntleyCompany Executive | Company Executive |
 Mem FerdaAhmed | Ahmed |
 Janice AcquahNisha | Nisha |
 Shola AdewusiAthena | Athena |
| LLukas RolfeLittle Lord | Little Lord |
| FFjokraLead Singer | Lead Singer |
 Max RinehartTeenage Kit | Teenage Kit |
| GGrace SchneiderJess (10 yrs) | Jess (10 yrs) |
| SSophie BrownScarlett (3 yrs) | Scarlett (3 yrs) |
 Lucinda RaikesTeacher | Teacher |
| SShaz LancasterRoadie (uncredited) | Roadie (uncredited) |
 Anjli MohindraKira | Kira |