Miss Tacuarembó is a unique mixture of drama, comedy, musical with touches of parody and nostalgia which for its beautiful narration will attract many open-minded viewers not only in Latin American world. The story of Natalia, the main hero, and her life's struggles is shown in different three eras of her life.
| Actor | Role |
|---|---|
 Natalia OreiroNatalia Prato 'Cristal' / Cándida López | Natalia Prato 'Cristal' / Cándida López |
 Mirella PascualHaydeé Prato | Haydeé Prato |
 Mike AmigorenaJesus Christ | Jesus Christ |
 Diego ReinholdCarlos | Carlos |
 Rossy de PalmaPatricia Peinado | Patricia Peinado |
 Alejandro TousFather Clever | Father Clever |
 Mónica VillaMónica | Mónica |
 Graciela BorgesMiss Gloria Marlene Coitiño | Miss Gloria Marlene Coitiño |
| JJeanette RodriguezNot listed | Not listed |
| JJulieta PetriellaMaría José | María José |
| MMelina PetriellaNot listed | Not listed |
| SSofía SilveraYoung Natalia | Young Natalia |
| MMateo CapoYoung Carlos | Young Carlos |
| BBoris BakstExpeditus | Expeditus |
| MMaría Pía PrattoNot listed | Not listed |
| EEma PrattoNot listed | Not listed |
| LLeonor CourtoisieNot listed | Not listed |
 Ale SergiNot listed | Not listed |