Someone at the prestigious Danforth Academy is trying to make the students sick. Is it Mia or Riley, the rich girls? Or could it be Emily, the Principal's daughter? Whoever it is, Abby, Paige, Claire and Taylor will have to put aside their differences and join together to solve the mystery!
| Actor | Role |
|---|---|
| KKelsey EdwardsAbby | Abby |
 Caitlin E.J. MeyerPaige | Paige |
 Danielle ChuchranClaire | Claire |
| LLauren FaberTaylor | Taylor |
 Jennette McCurdyMia | Mia |
 Savannah JaydeRiley | Riley |
| EEmma DukeEmily | Emily |
| BBrady EdwardsBrad | Brad |
 Andrew CottrillSean | Sean |
| EElijah ThomasEthan | Ethan |
| SSteve AndersonProfessor Plume | Professor Plume |
 Charan PrabhakarCoach Johnson | Coach Johnson |
 Frank GerrishSergeant Aimes | Sergeant Aimes |
 Susanne SutchyPrincipal Littman | Principal Littman |
| CClara Susan Morey IINurse Betty | Nurse Betty |
 K. Danor GeraldOscar | Oscar |
 Jennifer KlekasCoach Hallows | Coach Hallows |
| WWhitney LeeVanessa | Vanessa |
| TTatiana GalindoLindsay | Lindsay |
 Colleen BaumElsie | Elsie |
 JJ NewardKaren | Karen |
 Christy SummerhaysPauline | Pauline |
| SShauna ThompsonShelly | Shelly |
| DDakota EdwardsBen | Ben |
| SSamantha EndicottGracie | Gracie |
 Ruby Chase O'NeilMeena | Meena |
| SShelly FaberJanis | Janis |
| TTori RamertSamantha | Samantha |
| KKevin LydeCoach Thunder | Coach Thunder |
 Dhylan MeyerGeorge | George |