 Steve CarellGru (voice) | Gru (voice) |
 Pierre CoffinKevin / Stuart / Bob / Minions (voice) | Kevin / Stuart / Bob / Minions (voice) |
 Alan ArkinWild Knuckles (voice) | Wild Knuckles (voice) |
 Taraji P. HensonBelle Bottom (voice) | Belle Bottom (voice) |
 Michelle YeohMaster Chow (voice) | Master Chow (voice) |
 Julie AndrewsGru's Mom (voice) | Gru's Mom (voice) |
 Russell BrandDr. Nefario (voice) | Dr. Nefario (voice) |
 Jean-Claude Van DammeJean Clawed (voice) | Jean Clawed (voice) |
 Dolph LundgrenSvengeance (voice) | Svengeance (voice) |
 Danny TrejoStronghold (voice) | Stronghold (voice) |
 Lucy LawlessNun-Chuck (voice) | Nun-Chuck (voice) |
 Jimmy O. YangHenchman 1 (voice) | Henchman 1 (voice) |
 Kevin Michael RichardsonHenchman 2 (voice) | Henchman 2 (voice) |
 John DiMaggioHenchman 3 (voice) | Henchman 3 (voice) |
 RZABiker (voice) | Biker (voice) |
 Michael BeattieVNC Announcer / Guru Rick (voice) | VNC Announcer / Guru Rick (voice) |
 Will ArnettMr. Perkins (voice) | Mr. Perkins (voice) |
 Steve CooganSilas Ramsbottom (voice) | Silas Ramsbottom (voice) |
 Colette WhitakerGru's Teacher (voice) | Gru's Teacher (voice) |
 Raymond S. PersiBirthday Kid (voice) | Birthday Kid (voice) |
 Kyle BaldaAdditional Voices (voice) | Additional Voices (voice) |
 Bob BergenAdditional Voices (voice) | Additional Voices (voice) |
 Beau BillingsleaAdditional Voices (voice) | Additional Voices (voice) |
 Cathy CavadiniAdditional Voices (voice) | Additional Voices (voice) |
 David ChenAdditional Voices (voice) | Additional Voices (voice) |
 Will CollyerAdditional Voices (voice) | Additional Voices (voice) |
 Meilee CondronAdditional Voices (voice) | Additional Voices (voice) |
 Antonio Raul GarciaAdditional Voices (voice) | Additional Voices (voice) |
 Debi DerryberryAdditional Voices (voice) | Additional Voices (voice) |
 Scarlett EstevezAdditional Voices (voice) | Additional Voices (voice) |
