 Reese WitherspoonRosita (voice) | Rosita (voice) |
 Nick KrollGunter (voice) | Gunter (voice) |
 Nick OffermanNorman (voice) | Norman (voice) |
| OOscar JenningsPiglet (voice) | Piglet (voice) |
| LLeo JenningsPiglet (voice) | Piglet (voice) |
| CCaspar JenningsPiglet (voice) | Piglet (voice) |
| AAsa JenningsPiglet (voice) | Piglet (voice) |
 Pierre CoffinMinions (voice) | Minions (voice) |
 Jody GelbBarb / Ella (voice) | Barb / Ella (voice) |
 Dave RosenbaumDave (voice) | Dave (voice) |
 Eric OsmondAdditional Voices (voice) | Additional Voices (voice) |
 Chris RenaudMinions / Pipsqueak / Neanderthal Dad / The Animals (voice) | Minions / Pipsqueak / Neanderthal Dad / The Animals (voice) |
 Jenny SlateGidget (voice) | Gidget (voice) |
 Patton OswaltMax (voice) | Max (voice) |
 Gilbert GottfriedInfestor (voice) | Infestor (voice) |
 Bobby MoynihanMel (voice) | Mel (voice) |
 Jess HarnellAdditional Voices (voice) | Additional Voices (voice) |
 Mona MarshallAdditional Voices (voice) | Additional Voices (voice) |
 Brian T. DelaneyHal (voice) | Hal (voice) |
 Carlos AlazraquiGuard / Additional Voices (voice) | Guard / Additional Voices (voice) |
 John C. ReillyEddie (voice) | Eddie (voice) |
 Laraine NewmanEddie's Mom (voice) | Eddie's Mom (voice) |
 Brad MorrisGarry Wishmann (voice) | Garry Wishmann (voice) |
 Tara StrongGarry's Mom / Neanderthal Baby / Binky (voice) | Garry's Mom / Neanderthal Baby / Binky (voice) |
 Bill FarmerAdditional Voices (voice) | Additional Voices (voice) |
 Danny DeVitoThe Lorax (voice) | The Lorax (voice) |
 Ed HelmsOnce-ler (voice) | Once-ler (voice) |
 Michael KeatonWalter Nelson (voice) | Walter Nelson (voice) |
 Allison JanneyMadge Nelson (voice) | Madge Nelson (voice) |
 Matt KawczynskiSecurity Guard (voice) | Security Guard (voice) |
