Shorts from "The New Adventures of Mighty Mouse and Heckle and Jeckle" Saturday morning cartoon show edited together into a movie. Space cat villain Harry the Heartless holds space mouse Queen Pureheart. Only Mighty Mouse can save her.
| Actor | Role |
|---|---|
 Lou ScheimerMighty Mouse (voice) | Mighty Mouse (voice) |
 Diane PershingPearl Pureheart (voice) | Pearl Pureheart (voice) |
 Alan OppenheimerOil Can Harry (voice) | Oil Can Harry (voice) |