The final Mickey McGuire comedy finds Mickey and the gang putting together a medicine show in order to help out Hambone's Uncle Nemo.
| Actor | Role |
|---|---|
 Mickey RooneyMickey McGuire | Mickey McGuire |
 Billy BartyBilly McGuire | Billy McGuire |
| SShirley Jean RickertTomboy Taylor | Tomboy Taylor |
 Robert McKenzieAngry motorist | Angry motorist |
| BBobbie LentzLoud Three-Year Old | Loud Three-Year Old |
| JJimmy RobinsonHambone Johnson | Hambone Johnson |
 Marvin StephensKatrink | Katrink |
| SSpencer BellMan with gout | Man with gout |