Messalina was the Roman noblewoman who inveigled ageing emperor Claudio into marriage. Once ensconced on the throne, Messalina launched a reign of terror that shook the empire to its very foundations. The subject of countless film treatments, Rome's most villified empress is herein played by British actress Belinda Lee.
| Actor | Role |
|---|---|
 Belinda LeeValeria Messalina | Valeria Messalina |
 Spiros FocásLucius Maximus | Lucius Maximus |
 Giancarlo SbragiaAulo Celso | Aulo Celso |
 Carlo GiustiniLucius Geta | Lucius Geta |
 Arturo DominiciCaius Silius | Caius Silius |
 Ida GalliSilvia | Silvia |
 Giulio DonniniNarciso | Narciso |
 Marcello GiordaClaudio | Claudio |
 Mino DoroSulpicio | Sulpicio |
 Annie Gorassinicortigiana | cortigiana |
 Aroldo TieriPirgo Pollinice | Pirgo Pollinice |
 Giuliano GemmaMarcello | Marcello |
 Lia AngeleriVipidia | Vipidia |
 Vittorio CongiaOrtotrago | Ortotrago |
| SSpartaco NaleVibuleno | Vibuleno |
 Nando AngeliniGlauco | Glauco |
 Paola Pitagoraancella torturata | ancella torturata |
 Mimmo PoliNot listed | Not listed |
| NNino OrsiniNot listed | Not listed |
 Bruno ScipioniNot listed | Not listed |
 Benito StefanelliNot listed | Not listed |
 Calisto CalistiNot listed | Not listed |
 Bruna CealtiNot listed | Not listed |
| PPaola Di MarioNot listed | Not listed |
 Alberto PlebaniNot listed | Not listed |
| GGilberto MazziNot listed | Not listed |
 Roberto CaporaliNot listed | Not listed |
| AAntonio CoreviNot listed | Not listed |
 Alfio CaltabianoNot listed | Not listed |