 Fred MacMurrayAgent Dick Grant, alias Richard Hood | Agent Dick Grant, alias Richard Hood |
 Madge EvansHelen Sherwood | Helen Sherwood |
 David HoltDavid Sherwood | David Sherwood |
 Lynne OvermanAgent Gabby Lambert | Agent Gabby Lambert |
 John WrayGangster Sam "Red" Hammond | Gangster Sam "Red" Hammond |
 Leslie FentonMonk Gleason, gang boss | Monk Gleason, gang boss |
 Elizabeth PattersonElla Ferris | Ella Ferris |
 Grant MitchellAndrew Webster, banker | Andrew Webster, banker |
 Harry TylerLanky Gangster (script name: Steve) | Lanky Gangster (script name: Steve) |
| CClyde DilsonButch, beefy gangster | Butch, beefy gangster |
 George LloydLouie, beefier and dull-witted gangster | Louie, beefier and dull-witted gangster |
 Arthur AylesworthArea Agent Drew | Area Agent Drew |
 Helen ShipmanBecky Ferris | Becky Ferris |
 Herbert RawlinsonChief Agent Crawford | Chief Agent Crawford |
 Dean JaggerAgent Jones | Agent Jones |
 J. C. NugentMajor Newcomb, publisher | Major Newcomb, publisher |
 Hilda VaughnMiss Simpson, gang "nurse" | Miss Simpson, gang "nurse" |
 Paul FixCowardly Gangster in Getaway Launch | Cowardly Gangster in Getaway Launch |
 Frank SheridanKansas City Police Commissioner | Kansas City Police Commissioner |
 Phil TeadTalkative Reporter | Talkative Reporter |
| SSam GodfreyWiseguy Reporter | Wiseguy Reporter |
 Jack MulhallQuiet Reporter | Quiet Reporter |
| RRuss ClarkAgent Adams | Agent Adams |
 Frank ShannonAgent Joe | Agent Joe |
 Irving BaconOld-Timer on Bench | Old-Timer on Bench |
| AA.S. ByronPost Office Goofball | Post Office Goofball |
 Ben TaggartKansas City Police Chief | Kansas City Police Chief |
 Creighton HaleGroom | Groom |
 Oliver EckhardtUsher at Wedding | Usher at Wedding |
 Buddy RooseveltFBI Agent | FBI Agent |
