 Keith FergusonMegamind (voice) | Megamind (voice) |
 Laura PostRoxanne Ritchi (voice) | Roxanne Ritchi (voice) |
 Josh BrenerOI' Chum (voice) | OI' Chum (voice) |
 Maya TuttleKeiko Morita (voice) | Keiko Morita (voice) |
 Emily TuñonLady Doppler (voice) | Lady Doppler (voice) |
 Talon WarburtonLord Nighty-Knight (voice) | Lord Nighty-Knight (voice) |
 Scott AdsitPierre Pressure (voice) | Pierre Pressure (voice) |
 Chris SullivanBehemoth (voice) | Behemoth (voice) |
 Tony HaleMel / Mr. Donut / TV Announcer (voice) | Mel / Mr. Donut / TV Announcer (voice) |
 Adam LambertMachiavillain (voice) | Machiavillain (voice) |
 Jeanine MasonChristina Christo / Hostess (voice) | Christina Christo / Hostess (voice) |
 Michael BeattieEccentric Eddie (voice) | Eccentric Eddie (voice) |
 Eric FogelPolly 227 (voice) | Polly 227 (voice) |
 Todd HaberkornBig King Fish (voice) | Big King Fish (voice) |
| EEric MurphyBlue Mackerel (voice) | Blue Mackerel (voice) |
 Joey RudmanRed Snapper (voice) | Red Snapper (voice) |
 Roger Craig SmithMayor (voice) | Mayor (voice) |
 Carlos AlazraquiAdditional Voices (voice) | Additional Voices (voice) |
 Eric BauzaAdditional Voices (voice) | Additional Voices (voice) |
 Kimberly BrooksAdditional Voices (voice) | Additional Voices (voice) |
