For their first day on the job as the new protectors of Metro City, Megamind and Minion are selling off the gadgets from their evil lair. But when one seemingly harmless "button" unleashes the gigantic robot MEGA-MEGAmind, the duo will have to resort to their old tricks to restore order.
| Actor | Role |
|---|---|
 Will FerrellMegamind (voice) | Megamind (voice) |
 David CrossMinion (voice) | Minion (voice) |
| MMichelle BelforteConcerned Mother (voice) | Concerned Mother (voice) |
| JJordan Alexander HauserDamien (voice) | Damien (voice) |
| KKevin BaileyKevin (voice) | Kevin (voice) |
| DDante James HauserNigel (voice) | Nigel (voice) |
| DDeclan SwiftPeter (voice) | Peter (voice) |
| FFintan Thomas SwiftBarney (voice) | Barney (voice) |