 Matthew PerrySelf (archive footage) | Self (archive footage) |
 Morgan FairchildSelf | Self |
| EE. Martin EstradaSelf - U.S. Attorney for the Central District of California | Self - U.S. Attorney for the Central District of California |
| KKaty ForresterSelf - Journalist, The US Sun | Self - Journalist, The US Sun |
| GGreg KadingSelf - LAPD Detective, Ret. | Self - LAPD Detective, Ret. |
| DDeborah WalkerSelf - Journalist, The Hollywood Reporter | Self - Journalist, The Hollywood Reporter |
| DDavid FeifelSelf - Kadima Neuropsychiatry Institute | Self - Kadima Neuropsychiatry Institute |
| AAnna DavidSelf - Author, Party Girl | Self - Author, Party Girl |
 Hank AzariaSelf - Actor & Matthew's Friend | Self - Actor & Matthew's Friend |
 Jennifer O'NeillSelf - Former Celebrity Assistant | Self - Former Celebrity Assistant |
 Jennifer AnistonSelf - Actor & Co-Star (archive footage) | Self - Actor & Co-Star (archive footage) |
 Mark ChavezSelf - Physician (archive footage) | Self - Physician (archive footage) |
 Courteney CoxSelf - Actor & Co-Star (archive footage) | Self - Actor & Co-Star (archive footage) |
 Savannah GuthrieSelf - Co-Host, Today (archive footage) | Self - Co-Host, Today (archive footage) |
| KKenneth IwamasaSelf - Matthew's Personal Assistant (archive footage) | Self - Matthew's Personal Assistant (archive footage) |
 Marta KauffmanSelf - Co-Creator, Friends (archive footage) | Self - Co-Creator, Friends (archive footage) |
 David LettermanSelf - Host, Late Show with David Letterman (archive footage) | Self - Host, Late Show with David Letterman (archive footage) |
| CCody McLaurySelf - Ketamine Overdose Victim (archive footage) | Self - Ketamine Overdose Victim (archive footage) |
| CCaitlin MorrisonSelf - Matthew's Sister (archive footage) | Self - Matthew's Sister (archive footage) |
 Keith MorrisonSelf - Matthew's Stepfather (archive footage) | Self - Matthew's Stepfather (archive footage) |
 John Bennett PerrySelf - Matthew's Father (archive footage) | Self - Matthew's Father (archive footage) |
| SSalvador PlasenciaSelf - Physician (archive footage) | Self - Physician (archive footage) |
| JJasveen SanghaSelf - Ketamine Queen (archive footage) | Self - Ketamine Queen (archive footage) |
 Diane SawyerSelf - Journalist, ABC News (archive footage) | Self - Journalist, ABC News (archive footage) |
 Lisa KudrowSelf (archive footage) | Self (archive footage) |
 Matt LeBlancSelf (archive footage) | Self (archive footage) |
 David SchwimmerSelf (archive footage) | Self (archive footage) |
 Julia RobertsSelf (archive footage) | Self (archive footage) |
| EErik FlemingSelf - Director/Alleged 'Street Dealer' (archive footage) | Self - Director/Alleged 'Street Dealer' (archive footage) |
