After being separated for 15 years, the Sword of Power leads Prince Adam back to Eternia, where he discovers his home shattered under the fiendish rule of Skeletor. To save his family and his world, Adam must join forces with his closest allies, Teela and Duncan/Man-At-Arms, and embrace his true destiny as He-Man — the most powerful man in the universe.
| Actor | Role |
|---|---|
 Nicholas GalitzineAdam / He-Man | Adam / He-Man |
 Camila MendesTeela | Teela |
 Idris ElbaDuncan | Duncan |
 Jared LetoSkeletor | Skeletor |
 Alison BrieEvil-Lyn | Evil-Lyn |
 Jóhannes Haukur JóhannessonFisto | Fisto |
 Jon Xue ZhangRam Man | Ram Man |
 Sam C. WilsonTrap Jaw | Trap Jaw |
 James PurefoyKing Randor | King Randor |
 Charlotte RileyQueen Marlena | Queen Marlena |
 Morena BaccarinThe Sorceress | The Sorceress |
 Kristen WiigRoboto (voice) | Roboto (voice) |
 Tom WiltonCringer (voice) | Cringer (voice) |
 Christiaan BettridgeDian | Dian |
 Artie Wilkinson-HuntYoung Adam | Young Adam |
 Eire FarrellYoung Teela | Young Teela |
 James WilkinsonMekaneck | Mekaneck |
 Dolph LundgrenMacho Man | Macho Man |
 Kojo AttahTri-Klops | Tri-Klops |
 Hung Dante DongKarg | Karg |
| JJames AppsSpikor | Spikor |
 Hafþór Júlíus BjörnssonGoat Man | Goat Man |
| AArun BassiPigboy | Pigboy |
 Christian VunipolaHussein | Hussein |
 Sasheer ZamataSuzie | Suzie |
 Max KrausOfficer Black | Officer Black |
 Kelly CoughlinOfficer Blumenthal | Officer Blumenthal |
 Elena RiversJulie | Julie |
| SStephen AdentanMoss Man | Moss Man |
| MMichael BijokCastle Guard | Castle Guard |