The old friends from "The Mary Tyler Moore Show," Mary and Rhoda, are reunited, only to discover that Mary has a daughter named Rose and Rhoda's daughter is named Meredith.
| Actor | Role |
|---|---|
 Mary Tyler MooreMary Richards-Cronin | Mary Richards-Cronin |
 Valerie HarperRhoda Morgenstern-Rousseau | Rhoda Morgenstern-Rousseau |
 Elon GoldJonah Seimeier | Jonah Seimeier |
 Christine EbersoleCecile Andrews | Cecile Andrews |
 Bethany Joy LenzRose Cronin | Rose Cronin |
 Marisa RyanMeredith Rousseau | Meredith Rousseau |
 Steve RyanFather | Father |
 Mia DillonMother | Mother |
 Tommy HollisNews Cameraman | News Cameraman |
 Jeff SkowronGang Shooter | Gang Shooter |
 Rick GomezVideo Editor | Video Editor |
| EEddie KorbichPhotographer | Photographer |
 John RothmanEstate Lawyer | Estate Lawyer |
 James HandyDoorman | Doorman |
 Barbara GarrickGallery Curator | Gallery Curator |
 Joe ZaloomAirport Cab Driver | Airport Cab Driver |
| JJohn RoneyImpatient Cab Driver | Impatient Cab Driver |
 Jean De BaerMary Lookalike | Mary Lookalike |
 Michael WintherJob Interviewer | Job Interviewer |
 Charlie DayMailroom Kid | Mailroom Kid |
 Stewart ThorndikeGirl Model | Girl Model |