 Horst BuchholzMarco Polo | Marco Polo |
 Anthony QuinnKublai Khan | Kublai Khan |
 Orson WellesAkerman, Marco's Teacher | Akerman, Marco's Teacher |
 Bruno CremerGuillaume de Tripoli, a Knight Templar | Guillaume de Tripoli, a Knight Templar |
 Omar SharifSheik Alla Hou | Sheik Alla Hou |
 Robert HosseinPrince Nayam | Prince Nayam |
 Akim TamiroffThe Old Man of the Mountain | The Old Man of the Mountain |
 Elsa MartinelliThe Woman with the Whip | The Woman with the Whip |
 Grégoire AslanAchmed Abdullah | Achmed Abdullah |
 Massimo GirottiNicolo, Marco's Father | Nicolo, Marco's Father |
 Folco LulliSpinello, Venetian Merchant | Spinello, Venetian Merchant |
 Guido AlbertiPope Gregory X | Pope Gregory X |
 Jacques MonodNicolo de Vicenza, a Knight Templar | Nicolo de Vicenza, a Knight Templar |
 Miloje 'Mića' OrlovićMatteo, Marco's Uncle | Matteo, Marco's Uncle |
 Lynne Sue MoonPrincess Gogatine | Princess Gogatine |
 Maria Virginia OnoratoAlaou's Wife | Alaou's Wife |
| MMansoureh RihaiTaha | Taha |
 Michel BouquetNarrator (uncredited) | Narrator (uncredited) |
 Dragomir Felba(uncredited) | (uncredited) |
| AAndrej GardeninFencer (uncredited) | Fencer (uncredited) |
 Noël Howard(uncredited) | (uncredited) |
 Cliff Lyons(uncredited) | (uncredited) |
| MMyriam MichelsonChinese Princess (uncredited) | Chinese Princess (uncredited) |
| LLjubo Škiljević(uncredited) | (uncredited) |
 Lucille SoongPrincess Bride (uncredited) | Princess Bride (uncredited) |
 Aleksandar Stojković(uncredited) | (uncredited) |
 Janez Vrhovec(uncredited) | (uncredited) |
