The film, directed by Gregori J. Martin and co-directed by Darnell Williams, features a cast that includes Ilene Kristen, Forbes March, Aiden Turner, David Fumero, Jill Larson and Alex McCord. Manhattanites follows the lives of a group of people in New York City who are faced with life changing circumstances and decisions over a period of several months. The choices they makes have far reaching consequences on not only them but people they do not even know.
| Actor | Role |
|---|---|
 Ilene KristenMarilyn Marsden | Marilyn Marsden |
 Forbes MarchMatt Malone | Matt Malone |
 Aiden TurnerKyle Carpenter | Kyle Carpenter |
 Lev GornBlake Whitney | Blake Whitney |
 Gregori J. MartinCharlie Dean | Charlie Dean |
| CCaroline HayGretchen Styles | Gretchen Styles |
| TTasha GuevaraHannah Richards | Hannah Richards |
| MMatthew MartiniTodd Malone | Todd Malone |
 Jill LarsonMrs. Grimm | Mrs. Grimm |
 Monica BaileyRose | Rose |