Man and His Soul is a 1916 American silent melodrama film directed by John W. Noble.
| Actor | Role |
|---|---|
 Francis X. BushmanJohn Conscience / John Power | John Conscience / John Power |
 Beverly BayneMary Knowles | Mary Knowles |
 Edward BrennanReverend Edward Knowles | Reverend Edward Knowles |
| CCharles PrinceStephen Might Sr. | Stephen Might Sr. |
 John DavidsonStephen Might Jr. | Stephen Might Jr. |
 Helen DunbarMrs. Conscience, John's Mother | Mrs. Conscience, John's Mother |
 Grace ValentineEve | Eve |
| EEtta MansfieldNot listed | Not listed |
| FFred SittenhamNot listed | Not listed |
 Vera PearceNot listed | Not listed |