Mamele embraces the entire gamut of interwar Jewish life in Lodz--tenements and unemployed Jews, nightclubs and gangsters, religious Jews celebrating sukkot--but the film belongs to Molly Picon who romps undaunted through her dutiful daughter role saving siblings, keeping the family intact, singing and acting her way through the stages of a woman's life from childhood to old age.
| Actor | Role |
|---|---|
 Molly PiconKhavtshi Samet | Khavtshi Samet |
| EEdmund ZayendaSchlesinger | Schlesinger |
 Max BozykBerl Samet | Berl Samet |
| GGertrude BulmanBerta Samet | Berta Samet |
| SSimche FostelNadirman | Nadirman |
| OOla ShlifkoJentka Samet | Jentka Samet |
 Menasha OppenheimMaks Katz | Maks Katz |
| KKarol LatowiczZeisher | Zeisher |
| MMax PerelmanDawid Samet | Dawid Samet |
 Ruth TurkowBailchi | Bailchi |
| LLew SzrftzecerKonchicker | Konchicker |
 Maks BrynNot listed | Not listed |