 Annabelle WallisMadison Mitchell | Madison Mitchell |
 Maddie HassonSydney Lake | Sydney Lake |
 George YoungDetective Kekoa Shaw | Detective Kekoa Shaw |
 Michole Briana WhiteDetective Regina Moss | Detective Regina Moss |
 Susanna ThompsonJeanne | Jeanne |
 Ingrid BisuWinnie | Winnie |
 Jean Louisa KellyJane Doe | Jane Doe |
 Jake AbelDerek Mitchell | Derek Mitchell |
 Jacqueline McKenzieDr. Florence Weaver | Dr. Florence Weaver |
 Christian ClemensonDr. Victor Fields | Dr. Victor Fields |
 Amir AboulelaDr. Gregory | Dr. Gregory |
 Mercedes ColonMendez | Mendez |
 Ruben PlaOfficer Rubin | Officer Rubin |
 Jon Lee BrodyOfficer Lee | Officer Lee |
 Paula MarshallBeverly Woods | Beverly Woods |
 Zoë BellScorpion | Scorpion |
| SShaunte Lynette JohnsonBeta | Beta |
 Natalia SafranNurse Annie | Nurse Annie |
 Mike MendezHospital Security Guard #1 | Hospital Security Guard #1 |
| RRandy HaynieHospital Security Guard #2 | Hospital Security Guard #2 |
| CCord WalkerHospital Security Guard #3 | Hospital Security Guard #3 |
| JJesus TrujilloResearch Doctor | Research Doctor |
 Lisa CataraResearch Orderly | Research Orderly |
 Danielle NottinghamNews Anchor | News Anchor |
 Ray ChaseGabriel (voice) | Gabriel (voice) |
 Marina MazepaGabriel | Gabriel |
 Mckenna GraceYoung Madison | Young Madison |
 Madison WolfeYoung Serena | Young Serena |
 Andy BeanFrank | Frank |
 Patricia VelásquezNurse Velasquez | Nurse Velasquez |
