After years of "manually" trying to conceive, John and Katie Kelly put their bodies, wallet and marriage through the ringer of modern infertility treatments.
| Actor | Role |
|---|---|
 Eliza CoupeKatie Kelly | Katie Kelly |
 Steve HoweyJohn Kelly | John Kelly |
 Ed Begley Jr.Dr. Remis | Dr. Remis |
 Elizabeth RodriguezMaria | Maria |
 Bob StephensonGordon | Gordon |
 Glenne HeadlyBird | Bird |
 Jon DalyCaesar | Caesar |
 Jennifer LafleurDanica | Danica |
 Laird MacintoshOfficer Powers | Officer Powers |
 Anthony MarquezDallas | Dallas |
 Heidi GardnerMeg | Meg |
| SSarah MahmoodiTabby | Tabby |
 Eric NormingtonBrad | Brad |
 Pam CookNurse Virginia | Nurse Virginia |
| AAnnie CombsFertility Nurse | Fertility Nurse |
 Ericka KreutzNurse Bartlett | Nurse Bartlett |
 Ambrit MillhouseRoom 12 Nurse | Room 12 Nurse |
| JJulie WitnerDr. Hope | Dr. Hope |
 Juston StreetKenny | Kenny |
| JJoanie SearlePeyton | Peyton |
 Joe LorenzoCreepy Man | Creepy Man |
 Nicole PettisMrs. Berkus | Mrs. Berkus |
| AAdali McArthurLizzy | Lizzy |
| XXavier CharcasDougie | Dougie |
 Julianna GamizLisa | Lisa |
| BBrooke Taylor MaimenJill | Jill |
 Josh PafchekNate | Nate |
 Stephanie BentleyCourtney | Courtney |