Main Prem Ki Diwani Hoon is the story of Sanjana (Kareena Kapoor), a girl of today's generation full of life and vibrant ecstasy. She lives life on her own terms and gets very upset when her mother Susheela (Himani Shivpuri), arranges for her to see a boy leading to a marriage prospect.
| Actor | Role |
|---|---|
 Hrithik RoshanPrem Kishan Mathur | Prem Kishan Mathur |
 Kareena Kapoor KhanSanjana | Sanjana |
 Abhishek BachchanPrem Kumar | Prem Kumar |
 Himani ShivpuriSusheela | Susheela |
 Johny LeverJohnny | Johnny |
 Pankaj KapurSatyaprakash | Satyaprakash |
 Raju SrivastavaShambhu | Shambhu |
 Reema LagooPrem Kumar's Mother | Prem Kumar's Mother |
 Upasna SinghSecretary | Secretary |
 Tannaz IraniRoopa | Roopa |
 Vrajesh HirjeeReckless Driver | Reckless Driver |
 Javed JaffreyMan on mic | Man on mic |
 Farida JalalTeacher | Teacher |
 Shubha KhoteNot listed | Not listed |