A follow-up special to Madonna's recently released concert documentary film MADAME X. This special features questions from very special guests Ariana Grande, Amy Schumer, Billie Eilish, Doja Cat, Jimmy Fallon, Kim Kardashian, Snoop Dogg, and more.
| Actor | Role |
|---|---|
 MadonnaSelf | Self |
 Drew BarrymoreSelf | Self |
 Naomi CampbellSelf | Self |
 Doja CatSelf | Self |
 Anderson CooperSelf | Self |
 Snoop DoggSelf | Self |
 Billie EilishSelf | Self |
 Jimmy FallonSelf | Self |
 FKA twigsSelf | Self |
 Jean-Paul GaultierSelf | Self |
 Ariana GrandeSelf | Self |
 Jonah HillSelf | Self |
 Paris JacksonSelf | Self |
 Wyclef JeanSelf | Self |
 Kim KardashianSelf | Self |
 Swae LeeSelf | Self |
 David LettermanSelf | Self |
 Conor McGregorSelf | Self |
 Sarah PaulsonSelf | Self |
 Katy PerrySelf | Self |
 Jada Pinkett SmithSelf | Self |
 Amy SchumerSelf | Self |
 Lil Nas XSelf | Self |
| RRiccardo TisciSelf | Self |
 Kelly RipaSelf | Self |
 Donatella VersaceSelf | Self |
 Jeremy ScottSelf | Self |
 Lil WayneSelf | Self |
 JRSelf | Self |
 SymoneSelf | Self |