Lucy & Desi: Before the Laughter is described by CBS as "a dramatic love story" about the lives of Lucille Ball and Desi Arnaz.
| Actor | Role |
|---|---|
 Frances FisherLucille Ball | Lucille Ball |
| RRobin Pearson RoseVivian Vance | Vivian Vance |
| JJohn WheelerWilliam Frawley | William Frawley |
 Bette FordDe-De | De-De |
 Edith DiazMother Arnaz | Mother Arnaz |
 Matthew FaisonHarry | Harry |
 Liane LanglandMaureen O'Hara | Maureen O'Hara |
 Patrick CroninDoc Bender | Doc Bender |
 Alan OppenheimerArthur Lyons | Arthur Lyons |
| JJoyce BlairRoxana | Roxana |
 Don KeeferGrandpa Ball | Grandpa Ball |
 Roger RoseCousin Larry | Cousin Larry |
| JJim BrochuMax | Max |
 Rance HowardBernie | Bernie |
 Amanda CarlinMaid | Maid |
 Larry AndersonPercy | Percy |
 Maurice BenardDesi Arnaz | Desi Arnaz |