When Nurse Blue gets a job at the Hospital for the Sexually Insane, she knows she'll have her work cut out for her - after all, a ward full of orgasm addicts is enough to keep anyone's hands full. But when she arrives at the hospital the situation is crazier than she expected. The two directors of the hospital, Dr. Hook (John Holmes) and Dr. Fraud, practice a rather unusual form of therapy wherein sex is the key for recovery. Soon, Nurse Blue discovers that the hospital is filled with hysterical patients who believe they're doctors and nurses.
| Actor | Role |
|---|---|
 John HolmesDr. Hook | Dr. Hook |
 Crystal SyncNurce Nancy Blue | Nurce Nancy Blue |
 Jeffrey HurstNapoleon | Napoleon |
 Eric Edwardsde Sade | de Sade |
| JJeanette SinclairJustine | Justine |
 Dory DevonHead Nurse Florence Nightengale | Head Nurse Florence Nightengale |
 Marlene WilloughbyJosephine | Josephine |
 Ellen FaisonCleopatra | Cleopatra |
| TTerry AustinSexually Disturbed Patient (uncredited) | Sexually Disturbed Patient (uncredited) |
 Ursula AustinSexually Disturbed Patient (uncredited) | Sexually Disturbed Patient (uncredited) |
 Jenny BaxterBrunette at Orgy (uncredited) | Brunette at Orgy (uncredited) |
 Zebedy ColtPatient in Isolation (uncredited) | Patient in Isolation (uncredited) |
 Barbara DanielsNurse Candy (uncredited) | Nurse Candy (uncredited) |
 Roberta FindlayPasserby on Street (uncredited) | Passerby on Street (uncredited) |
| DDon PetersonDr. Fraud (uncredited) | Dr. Fraud (uncredited) |
| SSolange ShannonBrunette at Orgy (uncredited) | Brunette at Orgy (uncredited) |
 Tia von DavisBlonde at Orgy (uncredited) | Blonde at Orgy (uncredited) |