Dr. Burke Ryan is a successful self-help author and motivational speaker with a secret. While he helps thousands of people cope with tragedy and personal loss, he secretly is unable to overcome the death of his late wife. It's not until Burke meets a fiercely independent florist named Eloise that he is forced to face his past and overcome his demons.
| Actor | Role |
|---|---|
 Aaron EckhartBurke | Burke |
 Jennifer AnistonEloise Chandler | Eloise Chandler |
 Dan FoglerLane | Lane |
 Judy GreerMarty | Marty |
 Martin SheenDonald, Burke's Father-in-Law | Donald, Burke's Father-in-Law |
 Deirdre BladesShirley, Burke's Mother-in-Law | Shirley, Burke's Mother-in-Law |
 John Carroll LynchWalter | Walter |
 Sasha AlexanderJessica | Jessica |
 Frances ConroyEloise's Mom | Eloise's Mom |
 Joe AndersonTyler | Tyler |
 Clyde KusatsuCab Driver | Cab Driver |
 Anne Marie DeLuiseUnicom Executive | Unicom Executive |
| TTyler McClendonUnicom Executive | Unicom Executive |
 PanouUnicom Executive | Unicom Executive |
 Michael KopsaUnicom CEO | Unicom CEO |
 Michelle HarrisonCynthia | Cynthia |
 Darla FayBeehive | Beehive |
 Tom PickettDon | Don |
 Patricia HarrasLorraine | Lorraine |
 Maxine MillerBarbara | Barbara |
 Tim HenryWelling Eyes | Welling Eyes |
 Ellie HarvieMartha | Martha |
 Randall NewsomeWaiter | Waiter |
 Brandon Jay McLarenMohawk | Mohawk |
 Rekha SharmaNose-Ring | Nose-Ring |
 Alessandro JulianiTattoos | Tattoos |
 Elfina LukWorkshopper | Workshopper |