 Brendan FraserDJ Drake / Tasmanian Devil (voice) / She-Devil (voice) / Self | DJ Drake / Tasmanian Devil (voice) / She-Devil (voice) / Self |
 Jenna ElfmanKate | Kate |
 Steve MartinMr. Chairman | Mr. Chairman |
 Joe AlaskeyBugs Bunny-Daffy Duck / Beaky Buzzard / Sylvester / Mama Bear (voice) | Bugs Bunny-Daffy Duck / Beaky Buzzard / Sylvester / Mama Bear (voice) |
 Jeff BennettYosemite Sam / Foghorn Leghorn / Nasty Canasta (voice) | Yosemite Sam / Foghorn Leghorn / Nasty Canasta (voice) |
 Timothy DaltonDamien Drake | Damien Drake |
 Billy WestElmer Fudd / Peter Lorre (voice) | Elmer Fudd / Peter Lorre (voice) |
 Heather LocklearDusty Tails | Dusty Tails |
 Joan CusackMother | Mother |
 Bill GoldbergMr. Smith | Mr. Smith |
| DDon StantonMr. Warner | Mr. Warner |
 Dan StantonMr. Warner's Brother | Mr. Warner's Brother |
 Dick MillerSecurity Guard | Security Guard |
 Roger CormanHollywood Director | Hollywood Director |
 Kevin McCarthyDr. Bennell | Dr. Bennell |
 Jeff GordonSelf | Self |
 Matthew LillardSelf | Self |
 Mary WoronovAcme VP, Bad Ideas | Acme VP, Bad Ideas |
 Marc LawrenceAcme VP, Stating the Obvious | Acme VP, Stating the Obvious |
 Bill McKinneyAcme VP, Nitpicking | Acme VP, Nitpicking |
 George MurdockAcme VP, Unfairly Promoted | Acme VP, Unfairly Promoted |
 Robert PicardoAcme VP, Rhetorical Questions | Acme VP, Rhetorical Questions |
 Ron PerlmanAcme VP, Never Learning | Acme VP, Never Learning |
 Vernon WellsAcme VP, Child Labor | Acme VP, Child Labor |
 Leo RossiAcme VP, Climbing to the Top | Acme VP, Climbing to the Top |
 Archie HahnStunt Director | Stunt Director |
 Allan GrafInterrogator | Interrogator |
| AAustyn CucciaTour Bus Girl | Tour Bus Girl |
| MMarie-Claude JacquesFlower Vendor | Flower Vendor |
| MMichael AzriaParis Cafe Waiter | Paris Cafe Waiter |
