After a single, career-minded woman is left on her own to give birth to the child of a married man, she finds a new romantic chance in a cab driver. Meanwhile, the point-of-view of the newborn baby is narrated through voice-over.
| Actor | Role |
|---|---|
 John TravoltaJames | James |
 Kirstie AlleyMollie | Mollie |
 Olympia DukakisRosie | Rosie |
 George SegalAlbert | Albert |
 Abe VigodaGrandpa | Grandpa |
 Bruce WillisMikey (voice) | Mikey (voice) |
 Twink CaplanRona | Rona |
| JJason SchallerMikey | Mikey |
| JJaryd WaterhouseMikey | Mikey |
| JJacob HainesMikey | Mikey |
| CChristopher AydonMikey | Mikey |
 Joy BoushelMelissa | Melissa |
 Don S. DavisDr. Fleischer | Dr. Fleischer |
| LLouis HeckerlingLou | Lou |
 Brenda CrichlowSecretary | Secretary |
| AAndrea MannSalesgirl | Salesgirl |
| DDouglas TuckCab Stealer | Cab Stealer |
 Alex BruhanskiStreet Worker | Street Worker |
| CCasey GrantAdmitting Clerk | Admitting Clerk |
| OOscar B. RamosHospital Worker | Hospital Worker |
 Aurelio DinunzioOrderly | Orderly |
| JJeff IrvineAdmitting Doctor | Admitting Doctor |
| SShirley BarclayNurse | Nurse |
 William B. DavisDrug Doctor | Drug Doctor |
| DDavid BernerMr. Impatience | Mr. Impatience |
 Jerry WassermanMr. Anal | Mr. Anal |
| DDaliah NovakCarrie | Carrie |
| ZZena DarawallaLupe | Lupe |
 Nicholas RiceHarry | Harry |
 Neal IsraelMr. Ross | Mr. Ross |