During the summer of 1981, a group of friends in New York are completely unprepared for the onslaught of AIDS. What starts as a rumor about a mysterious "gay cancer" soon turns into a major crisis as, one by one, some of the friends begin to fall ill, leaving the others to panic about who will be next. As death takes its toll, the lives of these friends are forever redefined by an unconditional display of love, hope and courage.
| Actor | Role |
|---|---|
 Bruce DavisonDavid | David |
 Campbell ScottWilly | Willy |
 Patrick CassidyHoward | Howard |
 Mary-Louise ParkerLisa | Lisa |
 Stephen CaffreyFuzzy | Fuzzy |
 Dermot MulroneyJohn | John |
 John DossettPaul | Paul |
 Michael SchoefflingMichael | Michael |
 Brian CousinsBob | Bob |
| MMark LamosSean | Sean |
| TTanya BerezinOffice Manager | Office Manager |
 Welker WhiteRochelle | Rochelle |
| MMichael PiontekOffice Worker | Office Worker |
| JJoyce ReehlingOffice Worker | Office Worker |
 Marceline HugotSoap Opera Reader | Soap Opera Reader |
| MMargo SkinnerCasting Director | Casting Director |
| EEric GutierrezDisco Bartender | Disco Bartender |
| BBrad O'HareWaiter | Waiter |
 Philip MoonRestaurant Bartender | Restaurant Bartender |
 Hazel MedinaTriage Nurse | Triage Nurse |
 Annie GoldenHeroin Addict | Heroin Addict |
 Freda Foh ShenNurse with Addict | Nurse with Addict |
 Alexandra NeilSoap Actress | Soap Actress |
 Kelly ConnellMan with Soap Script | Man with Soap Script |
| RRajika PuriDr. Seth | Dr. Seth |
 Brent BarrettSoap Actor | Soap Actor |
| KKeith CharlesMartin | Martin |
 Dan ButlerWalter | Walter |
| RRobi MartinTransvestite | Transvestite |
 Robert JoyRon | Ron |