Annie (Ann Gillis), an orphan, (based on Harold Gray's comic strip but who is at no point in the film called 'Little Orphan Annie), is befriended by a fight manager, 'Pop' Corrigan (J. Farrell MacDonald). She brings him Johnny Adams (Robert Kent), a promising prizefighter. Annie gets the people of the neighborhood to finance his training. But on the night of Johnny's big fight, a gambling syndicate locks him in a gymnasium and it appears the neighborhood folks will lose their investment.
| Actor | Role |
|---|---|
 Ann GillisAnnie | Annie |
 Robert KentJohnny Adams | Johnny Adams |
 June TravisMary Ellen | Mary Ellen |
 J. Farrell MacDonald'Pop' Corrigan | 'Pop' Corrigan |
 J.M. KerriganTom Jennings | Tom Jennings |
 Margaret ArmstrongMrs. Jennings | Mrs. Jennings |
 Sarah PaddenMrs. Nora Moriarty | Mrs. Nora Moriarty |
 James BurkeMike Moriarty | Mike Moriarty |
| IIan MaclarenSoo Long | Soo Long |
 Dorothy VaughanMrs. Milligan | Mrs. Milligan |
 Ben WeldenSpot McGee | Spot McGee |
 Charles ColemanThe Butler | The Butler |
 Eddie GribbonMonk | Monk |
| VVince LombardiSka-Booch | Ska-Booch |
 Harry TylerO.O. Pike | O.O. Pike |