After the lord of darkness decides he will not cede his throne to any of his three sons, the two most powerful of them escape to Earth to create a kingdom for themselves. This action closes the portal filtering sinful souls to Hell and causes Satan to wither away. He must send his most weak but beloved son, Little Nicky, to Earth to return his brothers to Hell.
| Actor | Role |
|---|---|
 Adam SandlerNicky | Nicky |
 Patricia ArquetteValerie Veran | Valerie Veran |
 Harvey KeitelDad | Dad |
 Rhys IfansAdrian | Adrian |
 Tommy Lister Jr.Cassius | Cassius |
 Rodney DangerfieldLucifer | Lucifer |
 Allen CovertTodd | Todd |
 Peter DantePeter | Peter |
 Jonathan LoughranJohn | John |
 Robert SmigelBeefy | Beefy |
 Reese WitherspoonHolly | Holly |
 Dana CarveyReferee | Referee |
 Jon LovitzPeeper | Peeper |
 Kevin NealonGatekeeper | Gatekeeper |
 Michael McKeanChief of Police | Chief of Police |
 Quentin TarantinoDeacon | Deacon |
 Carl WeathersChubbs (uncredited) | Chubbs (uncredited) |
 Blake ClarkJimmy the Demon | Jimmy the Demon |
 Rob SchneiderThe Townie | The Townie |
 John WitherspoonStreet Vendor | Street Vendor |
 Clint HowardNipples | Nipples |
 Leah LailChrista | Christa |
 Jackie SandlerJenna | Jenna |
 Frank SiveroAlumni Hall Announcer | Alumni Hall Announcer |
 Lewis ArquetteCardinal | Cardinal |
 George WallaceMayor Randolph | Mayor Randolph |
| CChristopher CarrollHitler | Hitler |
 Ellen CleghorneMom | Mom |
| RReggie McFaddenDad | Dad |
 Philip BoldenSon | Son |