 Melissa GilbertLaura Ingalls Wilder | Laura Ingalls Wilder |
 Dean ButlerAlmanzo Wilder | Almanzo Wilder |
 Richard BullNels Oleson | Nels Oleson |
 Victor FrenchIsaiah Edwards | Isaiah Edwards |
 Kevin HagenDr. Hiram Baker | Dr. Hiram Baker |
 Allison BalsonNancy Oleson | Nancy Oleson |
 Stan IvarJohn Carter | John Carter |
 Pamela RoylanceSarah Carter | Sarah Carter |
| LLindsay KennedyJeb Carter | Jeb Carter |
| DDavid FriedmanJason Carter | Jason Carter |
 Shannen DohertyJenny Wilder | Jenny Wilder |
 Leslie LandonEtta Plum | Etta Plum |
| RRobert CasperSherwood Montague | Sherwood Montague |
 Patricia PearcyElsa Norris | Elsa Norris |
 Robin ClarkePatrick Norris | Patrick Norris |
| HHarvey VernonMr. Baker | Mr. Baker |
| JJoel GravesSam | Sam |
| JJ.S. 'Joe' YoungBeggar | Beggar |
| CColin HamiltonMr. Dodsworthy | Mr. Dodsworthy |
| SStephen RobertsDr. Langley | Dr. Langley |
 Kate WilliamsonNurse | Nurse |
| RRobert L. LeeTicket Agent | Ticket Agent |
 Henry KendrickSheriff #1 (as Hank Kendrick) | Sheriff #1 (as Hank Kendrick) |
| DDick ArmstrongSheriff #2 (as Richard Armstrong) | Sheriff #2 (as Richard Armstrong) |
| JJack DunlapSheriff #3 | Sheriff #3 |
| GGarin BougieButcher Boy | Butcher Boy |
| RRuth FosterMelinda Foster | Melinda Foster |
| JJack LilleyStagecoach Driver | Stagecoach Driver |
 Ike EisenmannErich Schiller (uncredited) | Erich Schiller (uncredited) |
| AAngella KayeSchool Girl (uncredited) | School Girl (uncredited) |
