 Daveigh ChaseLilo (voice) | Lilo (voice) |
 Chris SandersStitch / Leroy (voice) | Stitch / Leroy (voice) |
 Tia CarrereNani (voice) | Nani (voice) |
 Zoe CaldwellGrand Councilwoman (voice) | Grand Councilwoman (voice) |
 Kevin McDonaldPleakley (voice) | Pleakley (voice) |
 Kevin Michael RichardsonCaptain Gantu (voice) | Captain Gantu (voice) |
 Rob PaulsenReuben (voice) | Reuben (voice) |
 Jeff BennettDr. Jacques von Hämsterviel (voice) | Dr. Jacques von Hämsterviel (voice) |
 David Ogden StiersJumba (voice) | Jumba (voice) |
 Tara StrongAngel / Belle / Houdini / Pleakley's GACC Assistant (voice) | Angel / Belle / Houdini / Pleakley's GACC Assistant (voice) |
| DDebra RogersFirst Officer Ombit (voice) | First Officer Ombit (voice) |
 Ving RhamesCobra Bubbles (voice) | Cobra Bubbles (voice) |
 Liliana MumyMertle Edmonds (voice) | Mertle Edmonds (voice) |
 Frank WelkerSparky / Sprout / Mr. Stenchy / Kixx / Hoilo / Slugger (voice) | Sparky / Sprout / Mr. Stenchy / Kixx / Hoilo / Slugger (voice) |
 Nancy CartwrightShortstuff / Phantasmo (voice) | Shortstuff / Phantasmo (voice) |
 Bobcat GoldthwaitNosy (voice) | Nosy (voice) |
 Doug StoneEnsign Getco (voice) | Ensign Getco (voice) |
 Tress MacNeilleBonnie / Poxy / Gigi / Topper / Felix / Melty / Amnesio / Cannonball / GACC Van Computer (voice) | Bonnie / Poxy / Gigi / Topper / Felix / Melty / Amnesio / Cannonball / GACC Van Computer (voice) |
 Jim CummingsHeckler (voice) (uncredited) | Heckler (voice) (uncredited) |
 Jillian HenryElena (voice) | Elena (voice) |
| LLili IshidaYuki (voice) | Yuki (voice) |
 Rocky McMurrayClyde (voice) | Clyde (voice) |
| KKali WhitehurstTeresa (voice) | Teresa (voice) |
