After speaking at the Wakanda Embassy, Black Panther fights Thanos and fends him off with the help of fellow Avengers Captain America, Thor, Iron Man, Hulk, and Black Widow. After regaining conscious, Thanos is approached by Erik Killmonger and Ulysses Klaue in a plot where they will obtain the Vibranium in Wakanda to empower Thanos. When Black Panther discovers this plot, he must work with Shuri, Okoye, and the Avengers to defeat them.
| Actor | Role |
|---|---|
 James C. Mathis IIIT'Challa / Black Panther (voice) | T'Challa / Black Panther (voice) |
 Keston JohnErik Killmonger (voice) | Erik Killmonger (voice) |
 Yvette Nicole BrownOkoye (voice) | Okoye (voice) |
 Daisy LightfootShuri (voice) | Shuri (voice) |
 Isaac C. Singleton, Jr.Thanos (voice) | Thanos (voice) |
 Trevor DevallKlaue (voice) | Klaue (voice) |
 Mick WingertIron Man (voice) | Iron Man (voice) |
 Fred TatascioreHulk (voice) | Hulk (voice) |
 Laura BaileyBlack Widow (voice) / Reporter (voice) | Black Widow (voice) / Reporter (voice) |
 Roger Craig SmithCaptain America (voice) | Captain America (voice) |
 Travis WillinghamThor (voice) / Parking Attendant (voice) | Thor (voice) / Parking Attendant (voice) |
 Liam O'BrienDoctor Strange (voice) | Doctor Strange (voice) |