Comedy Central's Last Laugh '04 was a "year-in-review" type show where comedians talked about events in 2004. The show featured stand-up sets by Norm Macdonald, Kathy Griffin, D.L. Hughley, Gerg Giraldo, Bill Engval, and Colin Quinn. It also featured a comedic sketch by Andy Dick and guest appearances by Morgan Spurlock, David Cross, Michael Moore, and Zach Galifianakis as Jesus Christ. Modest Mouse and Snoop Dogg were musical guests for the show and performed "Float On" and "Drop It Like It's Hot," two of 2004's most popular songs.
| Actor | Role |
|---|---|
 David CrossSelf | Self |
 Andy DickHarlan McCraney | Harlan McCraney |
 Bill EngvallSelf | Self |
 Zach GalifianakisJesus | Jesus |
 Greg GiraldoSelf | Self |
 Kathy GriffinSelf | Self |
 Arianna HuffingtonSelf | Self |
 D.L. HughleySelf | Self |
 Denis LearySelf | Self |
 Norm MacdonaldSelf | Self |
 Michael MooreSelf | Self |
 Oscar NuñezLatino Man | Latino Man |
 Colin QuinnSelf | Self |
 Snoop DoggSelf | Self |
 Matt WalshDenis Leary's Lawyer | Denis Leary's Lawyer |
 Tara ReidSelf | Self |
 William ShatnerSelf | Self |
 Anna Nicole SmithSelf | Self |
 Morgan SpurlockSelf | Self |
 Angie StoneSelf | Self |