Hard times come for the Carraclough family and they are forced to sell their dog, Lassie, to the rich Duke of Rudling. Lassie, however, is unwilling to remain apart from young Carraclough son Joe and sets out on a long and dangerous journey to rejoin him.
| Actor | Role |
|---|---|
 Roddy McDowallJoe Carraclough | Joe Carraclough |
 Donald CrispSam Carraclough | Sam Carraclough |
 May WhittyDally | Dally |
 Edmund GwennRowlie Palmer | Rowlie Palmer |
 Nigel BruceDuke of Rudling | Duke of Rudling |
 Elsa LanchesterMrs. Helen Carraclough | Mrs. Helen Carraclough |
 Elizabeth TaylorPriscilla | Priscilla |
 Ben WebsterDan'l Fadden | Dan'l Fadden |
 J. Pat O'MalleyHynes | Hynes |
 Alan NapierJock | Jock |
 Arthur ShieldsAndrew | Andrew |
| JJohn RogersSnickers | Snickers |
 Alec CraigBuckles | Buckles |
 May BeattyWoman (uncredited) | Woman (uncredited) |
| GGeorge BroughtonAllen (uncredited) | Allen (uncredited) |
| SSherlee CollierLittle Girl (uncredited) | Little Girl (uncredited) |
| HHoward DaviesCobbler (uncredited) | Cobbler (uncredited) |
| HHugh HarrisonSchoolteacher on Stairway (uncredited) | Schoolteacher on Stairway (uncredited) |
| CCharles IrwinTom (uncredited) | Tom (uncredited) |
 Nelson LeighJoe's Teacher (uncredited) | Joe's Teacher (uncredited) |
| BBeverly LuffVillage Girl (uncredited) | Village Girl (uncredited) |
| JJohn PowerMiner (uncredited) | Miner (uncredited) |